AASLD 2010
Tenofovir (Viread) Maintains HBV Suppression without Resistance for 4 Years
- Details
- Category: HBV Treatment
- Published on Monday, 01 November 2010 12:48
- Written by Press Release
The nucleotide analog tenofovir (Viread) continued to demonstrate potent activity against hepatitis B virus (HBV) through 4 years, researchers reported at the American Association for the Study of Liver Diseases "Liver Meeting" (AASLD 2010) this week in Boston. In preliminary analyses from Study 102 (HBeAg negative patients) and Study 103 (HBeAg positive patients), HBV viral load remained suppressed, tenofovir was well-tolerated with only a few cases of elevated creatinine (a marker of impaired kidney function), and no drug-resistance mutations were detected. Subgroup analyses from the same studies showed that tenofovir worked well for Asian participants and people with high baseline HBV viral load.
Add-on adefovir (Hepsera) Is More Effective and Durable Than a Switch to entecavir (Baraclude) as Rescue Therapy for Epivir-resistant Patients with Chronic Hepatitis B
- Details
- Category: HBV Treatment
- Published on Tuesday, 19 October 2010 02:10
- Written by HIVandHepatitis.com
Adding Hepsera is more effective and durable than switching to Baraclude as rescue therapy for Epivir-resistant patients with chronic hepatitis B, according to a study presented in Boston last week at AASLD 2010. The mean reduction of serum HBV DNA levels was significantly less in the Entecavir group than in the add-on Hepsera group at weeks 24 and 48. In addition, the rate of undetectable HBV DNA was significantly lower in the Entecavir group than in the add-on Hepsera group.
CROI 2007: HCV May Be Sexually Transmitted in HIV Negative as Well as HIV Positive Men
- Details
- Category: HCV Sexual Transmission
- Published on Friday, 02 March 2007 00:00
- Written by Liz Highleyman
In recent years, outbreaks of apparently sexually transmitted hepatitis C virus (HCV) infection have been reported in London and Brighton in the UK and in a few European cities. In almost all cases, these acute HCV infections have occurred in HIV positive gay and bisexual men.
Flares during HBV Treatment Do Not Predict Response, May Cause Liver Failure
- Details
- Category: HBV Treatment
- Published on Sunday, 12 September 2010 00:00
- Written by Liz Highleyman
Developing hepatic flares, or sudden increases in liver enzymes or viral load, while undergoing nucleoside/nucleotide analog therapy for chronic hepatitis B did not increase the likelihood of sustained viral clearance and led to decompensated liver failure in some patients, researchers reported in the July 2011 Journal of Viral Hepatitis.
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